FOXO4-DRI reconstitution calculator

FOXO4-DRI at a glance

10mg vial + 3mL BAC water = 7.5 units = 250mcg — Frequency: daily, 16-week ladder — Best taken: evening

Full FOXO4-DRI dosing reference — reconstitution per vial size, dose-to-units table, side effects and sources.

What it does

• A senolytic peptide designed to selectively trigger death of aged ("senescent") cells, studied for anti-aging effects.
• Only studied in mice so far — the well-known 2017 study reversed some aging signs in older mice.
• No human trials or human dosing data exist — this is very early-stage research that warrants significant caution.
• One mouse study found this peptide reduced chemotherapy-related toxicity — a side-effect-reduction finding, not evidence of cancer prevention or treatment.
• Some community protocols instead use short pulses of much larger doses; no human data supports either.

Notes

All vial sizes reconstitute to 3.33mg/mL (33.3mcg/unit) so the syringe reads the same regardless of size.

Side Effects

• Injection site burning, fatigue, muscle soreness, nausea — anecdotal.
• Mild flu-like feeling, possibly from senescent-cell clearance; unconfirmed.
• No side effects in the 2017 mouse study — mouse data only.
• Theoretical long-term DNA-repair concern; unstudied beyond 30 days even in animals.

FOXO4-DRI vial sizes and concentrations

Standard water for each FOXO4-DRI vial size in the Dosify Me data, and the concentration it gives. One unit is 0.01 mL on a U-100 insulin syringe.

Worked example for FOXO4-DRI

1. The example vial: 10 mg of FOXO4-DRI, mixed with 3.00 mL of bacteriostatic water.
2. Concentration: 10 mg ÷ 3.00 mL = 3.33 mg/mL.
3. One syringe unit is 0.01 mL, so it holds 3.33 mg/mL × 0.01 mL = 0.033 mg (33.33 mcg).
4. Example quantity: 250 mcg = 0.25 mg.
5. Volume: 0.25 mg ÷ 3.33 mg/mL = 0.075 mL.
6. Syringe reading: 0.075 mL × 100 = 7.5 units.

Label numbers from the Dosify Me data, used to show the arithmetic. Not a recommendation of any quantity.

Frequently asked

How many units is 250 mcg of FOXO4-DRI?

At 3.33 mg/mL (the concentration every vial size mixes to), 250 mcg of FOXO4-DRI is 7.5 units on a 100-unit insulin syringe (0.075 mL).

How many units is 375 mcg of FOXO4-DRI?

At 3.33 mg/mL (the concentration every vial size mixes to), 375 mcg of FOXO4-DRI is 11.2 units on a 100-unit insulin syringe (0.113 mL).

How many units is 500 mcg of FOXO4-DRI?

At 3.33 mg/mL (the concentration every vial size mixes to), 500 mcg of FOXO4-DRI is 15.0 units on a 100-unit insulin syringe (0.150 mL).

How much bacteriostatic water do I add to a 10 mg vial of FOXO4-DRI?

3.00 mL, which gives 3.33 mg/mL. Other vial sizes use proportionally more or less water so the syringe reads the same.

How often is FOXO4-DRI taken?

Daily, 16-week ladder. Evening Typical cycle: 16-week daily ladder (community protocol; no human data).

Related pages and guides

• FOXO4-DRI dosing reference
• How many units is 250 mcg?
• How much bacteriostatic water for a 5 mg vial?
• U-100 vs U-50 insulin syringe for peptides
• Peptide storage and refrigeration
• All peptide guides

Other calculators

General peptide calculator · BAC water calculator · Peptide dosing chart · How to reconstitute peptides · mcg to units chart