Cagrilintide reconstitution calculator

Cagrilintide at a glance

5mg vial + 2mL BAC water = 10 units = 250mcg — Frequency: weekly — Best taken: same day each week

Full Cagrilintide dosing reference — reconstitution per vial size, dose-to-units table, side effects and sources.

What it does

• An amylin analog that activates amylin and calcitonin receptors in the hindbrain and brainstem — areas that sit outside the blood-brain barrier and directly sense fullness signals from the gut.
• Slows gastric emptying by roughly 40-50%, so food sits in the stomach longer and the feeling of fullness after a meal lasts longer.
• Suppresses hunger signals and reduces food-reward drive (the pull toward highly palatable food) through brain pathways that are separate from GLP-1 drugs like semaglutide — which is why combining the two produces an additive effect rather than just overlapping ones.
• Often studied and taken alongside GLP-1 drugs like semaglutide for exactly that reason.
• In clinical trials (as part of CagriSema) for obesity and type 2 diabetes, showing added weight loss on top of semaglutide alone.
• Not yet independently FDA-approved — still in late-stage clinical development as of this writing.
• As an amylin analog, cagrilintide also suppresses the pancreas's own glucagon release — the opposite direction from drugs that directly activate the glucagon receptor (like retatrutide, mazdutide, or survodutide). Since those drugs activate that receptor themselves rather than depending on the body's own glucagon, this is a theoretical tension rather than a confirmed one, and no published trial has studied cagrilintide combined with any of them.

Pramlintide, the FDA-approved amylin analog in this same drug class, carries a boxed warning for severe hypoglycemia when combined with insulin — insulin doses typically need to be reduced when starting an amylin analog. Cagrilintide also slows gastric emptying, which can change the absorption of other oral medications, including thyroid medication. Talk to your prescribing doctor before combining, especially if you use insulin.

Notes

The 5mg reference vial mixes to 2.5mg/mL. Larger vial size options are capped at ~3mL BAC water instead of diluted further, so they come out more concentrated (fewer units per dose) than this reference size.

Side Effects

• Nausea in ~20-47% depending on dose, peaking early in each dose step.
• Vomiting, diarrhea, constipation.
• Usually mild, resolving within 4-8 weeks.

Cagrilintide vial sizes and concentrations

Standard water for each Cagrilintide vial size in the Dosify Me data, and the concentration it gives. One unit is 0.01 mL on a U-100 insulin syringe.

^* This size is conventionally mixed more concentrated rather than diluted further — fewer units per dose than smaller vials of this peptide.

Syringe units for the listed quantities, by vial size

Worked example for Cagrilintide

1. The example vial: 10 mg of Cagrilintide, mixed with 3.00 mL of bacteriostatic water.
2. Concentration: 10 mg ÷ 3.00 mL = 3.33 mg/mL.
3. One syringe unit is 0.01 mL, so it holds 3.33 mg/mL × 0.01 mL = 0.033 mg (33.33 mcg).
4. Example quantity: 250 mcg = 0.25 mg.
5. Volume: 0.25 mg ÷ 3.33 mg/mL = 0.075 mL.
6. Syringe reading: 0.075 mL × 100 = 7.5 units.

Label numbers from the Dosify Me data, used to show the arithmetic. Not a recommendation of any quantity.

Frequently asked

How many units is 250 mcg of Cagrilintide?

At 2.5 mg/mL (the standard mix for vials up to 5 mg), 250 mcg of Cagrilintide is 10.0 units on a 100-unit insulin syringe (0.100 mL).

How many units is 600 mcg of Cagrilintide?

At 2.5 mg/mL (the standard mix for vials up to 5 mg), 600 mcg of Cagrilintide is 24.0 units on a 100-unit insulin syringe (0.240 mL).

How many units is 1.2 mg of Cagrilintide?

At 2.5 mg/mL (the standard mix for vials up to 5 mg), 1.2 mg of Cagrilintide is 48.0 units on a 100-unit insulin syringe (0.480 mL).

How much bacteriostatic water do I add to a 5 mg vial of Cagrilintide?

2.00 mL, which gives 2.5 mg/mL. Larger vials hold at most 3 mL of water, so they are mixed more concentrated and need fewer units per dose.

How much bacteriostatic water do I add to a 10 mg vial of Cagrilintide?

3.00 mL, which gives 3.33 mg/mL. This size holds at most 3 mL of water, so it is mixed more concentrated and the same dose is fewer units than from a smaller vial.

How often is Cagrilintide taken?

Weekly. Same day each week, with or without food Typical cycle: Often run continuously; tapering is done under guidance.

Is “cagri” the same as Cagrilintide?

Yes. “cagri” is the short name people use for Cagrilintide in forums and search, and every figure on this page is for that same compound. The units, water and schedule above do not change with the spelling.

Related pages and guides

• Cagrilintide dosing reference
• How many units is 250 mcg?
• How much bacteriostatic water for a 5 mg vial?
• U-100 vs U-50 insulin syringe for peptides
• Peptide injection site rotation
• All peptide guides

Other calculators

General peptide calculator · BAC water calculator · Peptide dosing chart · How to reconstitute peptides · mcg to units chart