PT-141 reconstitution calculator

PT-141 at a glance

10mg vial + 1mL BAC water = 10 units = 1mg — Frequency: 2x weekly — Best taken: ≥45 min before activity

Full PT-141 dosing reference — reconstitution per vial size, dose-to-units table, side effects and sources.

What it does

• Also known as Bremelanotide — acts on melanocortin receptors (MC3R/MC4R) in the brain rather than blood flow directly.
• FDA-approved (as Vyleesi) for hypoactive sexual desire disorder in premenopausal women.
• Also studied and used off-label for erectile dysfunction in men.
• Derived from Melanotan II, engineered to separate the sexual-desire effect from Melanotan's skin-tanning effect.

Causes a transient rise in blood pressure and drop in heart rate for several hours after dosing — the opposite direction from the nitrate warning people associate with this, which belongs to ED pills like sildenafil and appears nowhere in the label for PT-141's approved form. That label does list uncontrolled high blood pressure or known cardiovascular disease as reasons not to use it. Anyone on blood pressure medication should discuss timing and monitoring with their prescribing doctor first.

Notes

Reported amounts run from 500-750mcg up to a maximum of 1750mcg, used twice weekly. Standard mix is 10mg + 1mL BAC water (10 units = 1mg); the custom water field can go up to 3mL if you prefer it more diluted.

Side Effects

• Nausea in ~40%, worst with the first dose.
• Flushing (~20%), gone within hours.
• Injection site reactions (~13%), headache (~11%).
• Temporary blood pressure rise and heart-rate drop — controlled blood pressure before use is the listed precaution.

PT-141 vial sizes and concentrations

Standard water for each PT-141 vial size in the Dosify Me data, and the concentration it gives. One unit is 0.01 mL on a U-100 insulin syringe.

Worked example for PT-141

1. The example vial: 10 mg of PT-141, mixed with 1.00 mL of bacteriostatic water.
2. Concentration: 10 mg ÷ 1.00 mL = 10 mg/mL.
3. One syringe unit is 0.01 mL, so it holds 10 mg/mL × 0.01 mL = 0.1 mg (100 mcg).
4. Example quantity: 1750 mcg = 1.75 mg.
5. Volume: 1.75 mg ÷ 10 mg/mL = 0.175 mL.
6. Syringe reading: 0.175 mL × 100 = 17.5 units.

Label numbers from the Dosify Me data, used to show the arithmetic. Not a recommendation of any quantity.

Frequently asked

How many units is 500 mcg of PT-141?

At 10 mg/mL (the concentration every vial size mixes to), 500 mcg of PT-141 is 5.0 units on a 100-unit insulin syringe (0.050 mL).

How many units is 750 mcg of PT-141?

At 10 mg/mL (the concentration every vial size mixes to), 750 mcg of PT-141 is 7.5 units on a 100-unit insulin syringe (0.075 mL).

How many units is 1 mg of PT-141?

At 10 mg/mL (the concentration every vial size mixes to), 1 mg of PT-141 is 10.0 units on a 100-unit insulin syringe (0.100 mL).

How much bacteriostatic water do I add to a 10 mg vial of PT-141?

1.00 mL, which gives 10 mg/mL. Other vial sizes use proportionally more or less water so the syringe reads the same.

How often is PT-141 taken?

2x weekly. ≥45 min before activity Typical cycle: As needed — no fixed cycle.

Related pages and guides

• PT-141 dosing reference
• How many units is 250 mcg?
• How much bacteriostatic water for a 5 mg vial?
• U-100 vs U-50 insulin syringe for peptides
• Peptide injection site rotation
• All peptide guides

Other calculators

General peptide calculator · BAC water calculator · Peptide dosing chart · How to reconstitute peptides · mcg to units chart