LL-37

Reconstitution

Every vial size below is mixed to the same concentration, 2.5 mg/mL, so the syringe reads the same number of units for a given dose no matter which vial you bought.

Dose to syringe units

On a standard 100-unit (1 mL) insulin syringe, at the concentration above:

Amounts listed in the Dosify Me data: 100–400 mcg. Frequency: daily. Timing: morning, fasted.

All vial sizes reconstitute to 2.5mg/mL (25mcg/unit) so the syringe reads the same regardless of size.

Reading units for LL-37

• Syringe units measure volume, not the amount of LL-37: on a U-100 insulin syringe 100 units is 1 mL.
• The vial is labelled in mg while quantities are often written in mcg: 1 mg is 1000 mcg, so a 5 mg vial holds 5000 mcg.

Check one row of the table above: 100 mcg is 0.1 mg; 0.1 mg ÷ 2.5 mg/mL = 0.04 mL; 0.04 mL × 100 = 4 units.

What it does

• The only cathelicidin antimicrobial peptide naturally produced by the human body — part of the immune system's first line of defense.
• Studied for wound healing, skin conditions, and its broad antimicrobial activity.
• Experimental compound, not FDA-approved — essentially no established protocol for human use outside clinical studies.

Why it is listed under Immune System

• Immune System: Serves as a first line of defense in innate immunity.

What users report

Anecdotal and early-research reports, kept apart from the evidence above. Not clinically established.

• Users and some practitioners report clearing of stubborn infections and better wound healing — the antimicrobial claim it is used for.
• Some report improvement in chronic skin conditions such as psoriasis or slow-healing ulcers.
• Reports of reduced gut inflammation and biofilm-related symptoms circulate in practitioner protocols without trial evidence.

Side effects

• Injection site redness or discomfort, gone within hours.
• Mild fatigue as the immune system responds.
• Theoretical excessive immune activation at high doses.
• Very limited human safety data.

LL-37 calculator

Different vial or dose? Open the LL-37 reconstitution calculator, pre-filled with these numbers.

Frequently asked

How many units is 100 mcg of LL-37?

At 2.5 mg/mL (the concentration every vial size mixes to), 100 mcg of LL-37 is 4.0 units on a 100-unit insulin syringe (0.040 mL).

How many units is 200 mcg of LL-37?

At 2.5 mg/mL (the concentration every vial size mixes to), 200 mcg of LL-37 is 8.0 units on a 100-unit insulin syringe (0.080 mL).

How many units is 400 mcg of LL-37?

At 2.5 mg/mL (the concentration every vial size mixes to), 400 mcg of LL-37 is 16.0 units on a 100-unit insulin syringe (0.160 mL).

How much bacteriostatic water do I add to a 5 mg vial of LL-37?

2.00 mL, which gives 2.5 mg/mL. Other vial sizes use proportionally more or less water so the syringe reads the same.

How often is LL-37 taken?

Daily. Morning, fasted Typical cycle: 2 weeks on, ~1 week off; repeat 2–3×/year.

Sources

• The Human Cathelicidin Antimicrobial Peptide LL-37 for Polymicrobial Infected Wounds (PubMed)
• LL-37: structure, oligomerization and channel formation in membranes (Scientific Reports, Nature)
• Cathelicidin LL-37 exerts immunomodulatory effects via scavenger receptors (Int. J. Mol. Sci., MDPI)
• LL-37 as a potential treatment for polymicrobial infected wounds (Frontiers in Immunology)
• Cathelicidin LL-37 — overview (ScienceDirect Topics)

Related pages and guides

• LL-37 calculator
• How many units is 250 mcg?
• How much bacteriostatic water for a 5 mg vial?
• U-100 vs U-50 insulin syringe for peptides
• How to track peptide doses
• All peptide guides